Developing an Admin Page for a Plugin: state of the art

We need to develop an Admin Page within a WordPress Plugin.

We'd like to use React as JS-Framework, because many other Plugins do the same and it works for them. However, what about the CSS? Is using the WordPress CSS really the way to go?

It seems to be hard to use a proper CSS Framework inside of the WP Admin because of collisions. Furthermore, the Gutenberg Editor for example has a completely different interface (based on React also). Is it possible to do a similar thing?

I'd just like to know the way to go in terms of CSS (and maybe JS) in the WordPress Admin Pages.

Thank you.