What kind of hypothesis testing in Python can be used to validate that 4 job titles are significantly different based on their skillset?

I have 4 job titles, for each of which I scraped hundreds of job descriptions and classified them by if they contain words related to a predefined list of skills. For each job description, I now have a True/False parameter if they mention one of the skills. How can I validate that there is a significant difference between job descriptions that represent different job titles?

I'm very new to this topic and all I could think of is using dummy variables to make a multivariate linear regression. Not so sure if that is wise.